AGA technical review on hereditary colorectal cancer and genetic testing.

American Gastroenterological Association medical position statement: hereditary colorectal cancer and genetic testing.

This document presents the official recommendations of the American Gastroenterological Association (AGA) on Hereditary Colorectal Cancer and Genetic Testing. It was approved by the Clinical Practice and Practice Economics Committee on March 20, 2001, and the AGA Governing Board on April 18, 2001.

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies

Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...

American Gastroenterological Association Technical Review on the Diagnosis and Management of Lynch Syndrome.

Abbreviations used in this paper: AFAP, attenuated familial adenomatous polyposis; AGA, American Gastroenterological Association; AUC, area under the curve; CI, confidence interval; CRC, colorectal cancer; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colorectal cancer; IHC, immunohistochemistry; MAP, MUTYH-associated polyposis; MMR, mismatch repair; MSI, microsatellite in...

Genetic testing for young-onset colorectal cancer: case report and evidence-based clinical guidelines

BACKGROUND Young-onset colorectal cancer is clinicopathologically different from older-onset colorectal cancer and tends to occur in patients with hereditary germline conditions such as Lynch syndrome and familial adenomatous polyposis. CASE REPORT We describe the case of a 44-year-old man with a paternal history of colon polyps, a personal 2-year history of hematochezia, and a diagnosis of r...

Evaluation of MLH1 and MSH2 Gene Mutations in a Subset of Iranian Families with Hereditary Nonpolyposis Colorectal Cancer (HNPCC)